What is Methylcobalamin?

Methylcobalamin is the activated form of B12 and the preferred form of B12 in patients with MTHFR mutations.  

MTHFR stands for methylenetetrahydrofolate reductase. Deficiency may lead to high levels of homocysteine in the blood and low levels of folate and other vitamins. Those with an MTHFR genetic mutation are often at a higher risk of B12 deficiency and need to supplement. Methylcobalamin is essential for the normal metabolism of folate. Without methylcobalamin, folate cannot be used effectively by the body.

What is the difference between a traditional B12 shot (cyanocobalamin) and methylcobalamin?

Cyanocobalamin is a synthetic, inactive form of vitamin B12 found only in supplements. It is FDA-approved for the treatment of vitamin B12 deficiency.

Methylcobalamin is one of the two natural and bioactive coenzyme forms of vitamin B12 (the other is adenosylcobalamin). It is the most abundant form in human plasma and is also present naturally in foods. Methylcobalamin is the active form of vitamin B12 and doesn’t need an extra step for conversion. Methylcobalamin helps reduce homocysteine to methionine through a methylation process. 

At BreatheSW, we carry both cyanocobalamin and methylcobalamin. Visit our website to schedule, walk-ins are also welcome.